Fenogard 200

৳ 210

Generic Name: Fenofibrate BP
Therapeutic Class: Fibrate

View Prescribing Details

Additional information

STRENGTH

200mg

Presentation

Fenogard 200 Capsule: Each capsule contains Fenofibrate BP 200 mg.

Description

Fenofibrate is a fibric acid derivative. Fenofibrate is rapidly hydrolyzed after oral ingestion to its pharmacologically active form, fenofibric acid. Fenofibric acid cause reduction in total cholesterol, LDL cholesterol, Apo-lipoprotein B, Total triglycerides and VLDL. In addition, treatment with fenofibrate results in increases in HDL and apo-proteins, apo Al & apo All. Fenofibrate also reduces serum uric acid levels in hyperuricemic and normal individuals by increasing the urinary excretion of uric acid. The micronized form of Fenofibrate has enhanced absorption over the non-micronize formulation.

Indication

Fenofibrate is indicated for indication for hyperlipidemias of type lla, IIb, III, IV and V in patients who have not responded adequately to diet & other appropriate measures.

 Dose And Administration

Fenogard capsule 200 mg once daily is recommended as the dose for the treatment of primary hypercholesterolemia, hypertriglyceridemia or mixed hyperlipidemia. Absorption of Fenofibrate is increased by approximately 35% when administered with food.

Side Effects

a) Common: Gastro-intestinal disturbances (e.g. nausea, anorexia, and gastric pain), pruritus, urticarial, impotence, headache, dizziness, vertigo

b) Rare: Side effects that may be seen very rarely include fatigue, hair loss, myotoxicity.

Warning and Precaution

Special care needed in patients with renal disease, as progressive increases in serum creatinine concentration or failure to follow dosage guidelines may result in myotoxicity; discontinue if myotoxicity suspected or creatinine kinase concentration increases significantly. Liver function tests recommended every 3 months for first year.

Contraindication

Fenofibrate is contraindicated in patients with hypersensitivity to Fenofibrate, severe renal or hepatic impairment, existing gall bladder disease, pregnant women & breast feeding mothers, photosensitivity to ketoprofen.

Use In Pregnancy And Lactation

Fenofibrate is not recommended for pregnant woman. Fenofibrate is not recommended in nursing mother.

Packaging

Fenogard 200 capsule: Each box contains 3X 10’s capsules in Alu-PVC blister.

Drug Interaction

a) With medicine: Fenofibrate has been reported to potential the anticoagulant effects of warfarin. Also fenofibrate may increase the nephrotoxicity of cyclosporine. Due to a potential increase the risk of rhabdomyolysis. cautions should be taken against the use of Fenofibrate with HMG-CoA reducates inhibitors unless the benefits outweigh the risks. However the use of low-dose statins with Fenofibrate appears to be well tolerated.

b) With Food and others: Avoid driking alcohol while taking fenofibrate, can result in liver damage, Therefore avoid the combination of alcohol with fenofibrate.

Overdose

There is no specific treatment for overdose with Fenofibrate. General supportive care of the patient is indicated, including monitoring of vital signs and observation of clinical status, should an overdose occur. If indicated, elimination of unabsorbed drug should be achieved by emesis or gastric lavage; usual precautions should be observed to maintain the airway. Because fenofibrate is highly bound to plasma proteins, hemodialysis should not be considered.

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