Flumazole 50

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Generic Name: Fluconazole USP
Therapeutic Name: Anti-Fungal

View Prescribing Details

Additional information

STRENGTH

50mg

Presentation

Flumazole 50 Capsule: Each capsule contains Fluconazole USP 50 mg.

Flumazole 150 Capsule: Each capsule contains Fluconazole USP 150 mg.

Description

Fluconazole is a triazole antifungal drug which acts by inhibition of the ergosterol component of the fungal cell membrane. It is active against a broad spectrum of fungal pathogens and is available for oral use. Following oral administration, absorption is rapid and extensive (>90%). Bioavailability is the same in the fastinglability of Fluconazole is unaffected by gastric pH. The plasma half life is approximately 30 Hours. The plasma protein binding of fluconazole is low, at 11 % and the drugs is widely distributed throughout the body. Most of the dose of fluconazole is excreted unchanged in the urine, the reminder of the dose being eliminated in the urine as metabolites.

Indication

Flumazole is indicated in the treatment of acute or recurrent vaginal candidiasis, mucosal candidiasis (as oropharyngeal candidiasis, oesophagitis, candiduria), systemic candidiasis and cryptococcal infections (including meningitis).

Dose And Administration

Adults: Since oral absorption is rapid and almost complete, the daily dose of Fluconazole is the same for oral and intravenous administration.

Side Effects

a) Common: Generally side effects are nausea, abdominal discomfort, diarrhea and flatulence, occasionally abnormalities of liver enzymes of Fluconazole.

b) Rare: Rarely side effects are rash, angioedema and anaphylaxis reported of Fluconazole.

Warning & Precaution

Caution should be taken in renal impairment, pregnancy and breast feeding and in raised liver enzymes.

Contraindication

Fluconazole is contraindication to patients hypersensitive to this drug and in advanced liver disease.

Use In Pregnancy And Lactation

Fluconazole is not recommended for use in during pregnancy or nursing mother. The use of Fluconazole in lactating mothers is not recommended.

Packaging

Flumazole 50 capsule: Each box containing 30’s capsules in Alu-Alu blister pack.

Flumazole 150 capsule: Each box containing 10’s capsules in Alu-Alu blister pack.

Drug Interaction

a) With medicine: Rifampicin reduces plasma concentration of Fluconazole. Effects of nicoumalone, phenytoin and warfarin are enhanced. Plasma concentrations of sulphonyl, ureas & theophyline are possibly increased.

b) With Food and others: Fluconazole should not coadministrate with alcohol or tobacco, theses can cause headaches and stomach discomfort.

Overdose

There have been reports of overdose with fluconazole accompanied by hallucination and paranoid behavior.

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