Xiroket IM/IV
৳ 55
Brand Name: Xiroket IM/IV
Generic Name: Ketorolac Tromethamine USP
Theraapeutic Class: Analgesic & Antipyretic
- Additional information
- Presentation
- Description
- Indication
- Dose And Administration
- Side Effects
- Warning & Precaution
- Contraindication
- Use In Pregnancy And Lactation
- Packaging
- Drug Interaction
- Overdose
- Reviews (0)
Additional information
| STRENGTH | 30mg |
|---|
Presentation
XIROKET Injections: Each ml contains Ketorolac Tromethamine USP 30 mg.
Description
XIROKET is a potent analgesic of the non-steroidal anti-inflammatory drugs (NSAID). It inhibits the cyclo-oxygenase enzyme system and hence prostaglandin synthesis. Thus it gives minimal inflammatory effect at its analgesic effect.
Indication
XIROKET ampoules are indicated for the short-term management of moderate to severe acute postoperative pain.
Dose And Administration
Adults: The recommended initial dose of XIROKET is 10 mg, followed by 10-30 mg every 4 to 6 hours as required. In the initial postoperative period, XIROKET may be given as often as every 2 hours if needed. The lowest effective dose should be given. The maximum duration of treatment should not exceed 2 days.
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Types of patients
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Single dosage
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Double dosage
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IV |
IM |
IV |
IM |
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≥2 years
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0.5 mg/kg |
1 mg/kg |
Initially 0.5 mg/kg then 0.5 mg/kg every 6 hour for maximum 2 days |
—————— |
| < 65 years |
10-30 mg |
10-60 mg
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10-30 mg every 6 hour. Daily 120 mg for maximum 5 days | 10-30 mg every 4 hour. Daily 120 mg for maximum 5 days |
| ≥65 years or renal impairment or under 50 kg
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10-15 mg |
10-30 mg |
10-15 mg every 6 hour. Daily 60 mg for maximum 5 days
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10-15 mg every 4-6 hour. Daily 60 mg for maximum 5 days
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Geriatric Use (≥65 Years of Age): Because ketorolac tromethamine may be cleared more slowly by the elderly who are also more sensitive to the dose-related adverse effects of NSAIDs, extreme caution and reduced dosages and careful clinical monitoring must be used when treating the elderly with ketorolac tromethamine.
Side Effects
a) Common: Commonly occurring side-effects are nausea, vomiting, gastro-intestinal bleeding, melaena, peptic ulcer, pancreatitis, anxiety, drowsiness, dizziness, headache, hallucinations, excessive thirst, inability to concentrate, insomnia, malaise, fatigue, pruritus, urticaria, skin photosensitivity, Lyell’s syndrome, Stevens Johnson syndrome, flushing.
b) Rare: Bradycardia, hypertension, palpitations, chest pain, infertility in female, dyspnoea, asthma, pulmonary edema, fever, injection site pain.
Warning & Precaution
Since ketorolac tromethamine and its metabolites are excreted primarily by the kidney, patients with moderate to severe impairment of renal function should not receive. Asthma & pregnant patients should used with caution.
Contraindication
Ketorolac Tromethamine is contraindicated in patients with known hypersensitivity to NSAIDs and any of the components of the product. Moreover, the patient with the history of asthma, nasal polyp, angioedema, peptic ulcer and bleeding, bleeding disorders are contraindicated for this drug.
Use In Pregnancy And Lactation
Safety in human pregnancy has not been established. Ketorolac has been detected in human milk at low levels. Ketorolac is therefore contraindicated during pregnancy, labour or delivery, or in mothers who are breast feeding.
Packaging
XIROKET Injection: Each box containing 1X1 ampoule in blister pack.
Drug Interaction
a) With Medicine: Ketorolac tromethamine should not be used with other NSAIDs, aspirin, anti-coagulants Ketorolac, other non-steroidal anti-inflammatory drugs, the anti-hypertensive effect of beta-blockers and ACE inhibitors, particularly in volume depleted patients. Caution is advised when methotrexate is administered concurrently, since some prostaglandin synthesis inhibiting drugs have been reported to reduce the clearance of methotrexate, and thus possibly enhance its toxicity. Probenecid should not be administered
b) With food: No interaction with food.
Overdose
Doses of 360 mg given intramuscularly over and 8 hour interval for 5 consecutive days have caused abdominal pain and peptic ulcers which have healed after discontinuation of dosing.
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