Xiroket 10

৳ 270

Brand Name: Xiroket 10
Generic Name: Ketorolac Tromethamine USP
Therapeutic Class: Analgesic & Antipyretic

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Additional information




XIROKET Tablet: Each film coated tablet contains Ketorolac Tromethamine USP 10 mg.


XIROKET is a potent analgesic of the non-steroidal anti-inflammatory drugs (NSAID). It inhibits the cyclo-oxygenase enzyme system and hence prostaglandin synthesis. Thus it gives minimal inflammatory effect at its analgesic effect.


XIROKET tablets are indicated for the short-term management of moderate postoperative pain.

Dose And Administration

Tablets: The recommended oral dose of XIROKET is 10 mg every 4 to 6 hours for pain as required. Doses exceeding 40 mg per day are not recommended. For patients receiving Ketorolac Tromethamine ampoules, and who are converted to XIROKET tablets, the total combined daily dose should not exceed 90 mg (60 mg for the elderly, renal-impaired patients and patients less than 50 kg) and the oral component should not exceed 40 mg on the day the change of formulation is made. Patients should be converted to oral treatment as soon as possible.

A total daily dose of 90 mg for non-elderly and 60 mg for the elderly, renal-impaired patients and patients less than 50 kg should not be exceeded.

Geriatric Use (265 Years of Age): Because ketorolac tromethamine may be cleared more slowly by the elderly who are also more sensitive to the dose-related adverse effects of NSAIDs, extreme caution and reduced dosages and careful clinical monitoring must be used when treating the elderly with ketorolac tromethamine.

Side Effects

a) Commonly occurring side-effects are nausea, vomiting, gastro-intestinal bleeding, melaena, peptic ulcer, pancreatitis, anxiety, drowsiness, dizziness, headache, hallucinations, excessive thirst, inability to concentrate, insomnia, malaise, fatigue, pruritus, urticaria, skin photosensitivity, Lyell’s syndrome, Stevens Johnson syndrome, flushing.

b) Rear: bradycardia, hypertension, palpitations, chest pain, infertility in female, dyspnoea, asthma, pulmonary edema, fever, injection site pain.

Warning & Precaution

Patients over the age of 65 years may be at a greater risk of experiencing adverse events than younger patients. Ketorolac tromethamine can cause gastro-intestinal irritation, ulcers or bleeding in patients with or without a history of previous symptoms. Bronchospasm may be precipitated in patients with a history of asthma. Since ketorolac tromethamine and its metabolites are excreted primarily by the kidney, patients with moderate to severe impairment of renal function (serum creatinine greater than 160 micromol/l) should not receive. Fluid retention and oedema have been reported with the use of Ketorolac tromethamine.


Ketorolac Tromethamine is contraindicated in patients with known hypersensitivity to NSAIDs and any of the components of Ketorolac Tromethamine. Moreover, the patient with the history of asthma, nasal polyp, angioedema, peptic ulcer and bleeding, bleeding disorders are contraindicated for this drug.

Use In Pregnancy And Lactation

Safety in human pregnancy has not been established. Ketorolac has been detected in human milk at low levels. Ketorolac is therefore contraindicated during pregnancy, labour or delivery, or in mothers who are breast feeding.


XIROKET 10 tablet: Each box contains 3×10’s blister pack.

Drug Interaction

a) With Medicine: Ketorolac tromethamine should not be used with other NSAIDs, aspirin, anti-coagulants Ketorolac, other non-steroidal anti-inflammatory drugs, the anti-hypertensive effect of beta-blockers and ACE inhibitors, particularly in volume depleted patients. Caution is advised when methotrexate is administered concurrently, since some prostaglandin synthesis inhibiting drugs have been reported to reduce the clearance of methotrexate, and thus possibly enhance its toxicity. Probenecid should not be administered

b) With Food and others: should not take with alcohol (ethanol) and milk.


Symptoms: Abdominal pain, nausea, vomiting, hyperventilation, peptic ulceration, erosive gastritis and renal dysfunction.

Management: Symptomatic and supportive treatment. Consider gastric lavage or admin of activated charcoal within 1 hr. of ingestion.


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