Generic Name: Ketoprofen BP
Therapeutic Class: Analgesic & Antipyretic
- Additional information
- Dose And Administration
- Warning & Precaution
- Use In Pregnancy And Lactation
- Side Effects
- Drug Interaction
- Reviews (0)
Zerofen 50 tablet: Each enteric-coated tablet contains Ketoprofen BP 50mg.
Zerofen 100 tablet: Each enteric-coated tablet contains Ketoprofen BP 100mg.
Ketoprofen is a pharmacopoeial non-steroidal anti-inflammatory drug (NSAID). It is a strong inhibitor of prostaglandin synthetase and potent analgesic agent. Studies in vitro and in vivo show that ketoprofen possesses powerful anti-inflammatory, antipyretic, anti-bradykinin and lysosomal membrane stabilizing properties. Ketoprofen is almost completely absorbed from the gastrointestinal tract. Peak plasma levels are attained within 2 to 4 hours after the oral administration of Zerofen tablets. The drugs are 99% bound to plasma proteins mainly to the albumin fraction. Metabolites as well as the unchanged drug are excreted mainly in the urine. The elimination half-life is 2-3 hours. There is no accumulation on continued daily dosing. Maximun plasma concentration occurs after 6-8 hours. It declines thereafter with a half-life of about 8 hours.
Zerofen a potent non- steroidal anti-inflammatory analgesic agent and a strong inhibitor of prostaglandin synthetase. Zerofen is recommended in the management of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis. Acute articular and per articular disorders (bursitis, capsulitis, synovitis, tendonitis), cervical spondylitis, low back pain (strain, lumbago, sciatica, fibrositis), painful musculo-skeletal conditions and dysmenorrhea. Zerofen reduces joint pain and inflammation and facilitates increase in mobility and function independence. As with other nonsteroidal anti-inflammatory agents, it does not cure the underlying diseases. Zerofen is also indicated for the relief of mild to moderate acute pain associated with musculotendinous tranuma (sprains and strains), post-operative(including dental surgery) or postpartum pain.
Dose And Administration
Zerofen enteric coated tablets should preferably be taken one to two hours before meals or at last two hours after meals. The tablets should be swallowed and not to be broken, crushed or chewed. Oral dose is 50-100 mg twice daily, depending on patient weight and on severity of symptoms; medication should be taken early in the morning and late at night. Elderly: There is no evidence of excess of adverse reactions in the elderly
Warning & Precaution
Ketoprofen should be given with caution to the children under 15 years and patients with a history of recurrent peptic ulceration. Inhibition of renal prostaglandin synthesis by non-steroidal anti-inflammatory agents may interfere with renal function especially in the presence of existing renal disease. Ketoprofen should, therefore, be used with caution in patient with renal impairment
ketoprofen is contra-indicated in active peptic ulceration, a history of recurrent peptic ulceration or chronic dyspepsia, several renal dysfunction and severe hepatocellular dysfunction, disease in children (safetyl dosage during long-term treatment has not been established). Ketoprofen should not be given to patients sensitive to aspirin or other non-steroidal anti-inflammatory agents.
Use In Pregnancy And Lactation
No embryopathic effects have been demonstrated in animals idemiological evidence of the safety of ketoprofen in human pregnancy. Nevertheless it is recommended to avoid ketoprofen unless considered essential in which case it should be discontinued within one week of expected confinement when NSAID might cause premature closure of the ductus arteriosus or persistent pulmonary hypertension in the neonate. They may also delay labour. Trace amounts of ketoprofen are excreted in the breast milk; avoid use of ketopofen unless considered essential. Use in children & adolescents: Is not established
Zerofen 50 tablet: Each Box contains 5 X 10’s tablets in Alu-PVC blister pack.
Zerofen 100 tablet: Each Box contains of 3 X 10’s tablets in Alu-PVC blister pack.
a) Common: Minor adverse effects, frequently transient, consist for the most part of gastrointestinal effects such as indigestion, diarrhoea, dyspepsia, nausea, constipation, heart burn and various types of abdominal discomfort.
b) Rare: Major gastrointestinal adverse effect such as peptic ulceration, haemorrhage or perforation may rarely occur. Major adverse effect involving other organ systems such as hematological, reaction, hepatic or renal damage, dermatological reactions, bronchospasm and anaphylaxis are exceedingly rare.
a) With Medicine: ketoprofen is highly protein- bound. Ketoprofen may increase or reduce the activity of some drugs concomitant use of other protein binding drugs, e.g. anticoagulants, sulphonamides, hydantions, might necessitate modification of dosage in order to avoid increased levels of such drugs resulting from competition for plasma protein-binding sites. Avoid association with: -Lithium: ketoprofen increase lithium level. Dosage of lithium should be modified during and after combined therapy. -Methotrexate: ketoprofen increases the haematological toxicity of methotrexate. -Triciopidine: Increases of the platelet anti-agent activity occurs. Other non-steroidal anti-inflammatory drugs in hamorrhags and ulcer.
b) With Food and others: ketoprofen should not co-administrate with Milk. Taking milk with ketoprofen can decrease absorption of ketoprofen.
like other propionic acid derivatives, ketoprofen is low toxicity in overdosage; symptoms after acute ketoprofen intoxication are largely limited to drowsiness, abdominal pain and vomiting, but adverse effect’s seen after overdosage with propionic acid derivatives such as hypotension, bronchosdpasm and gastrointestinal hamorrage.